Seasonal malaria chemoprevention in a context of high presumed sulfadoxine-pyrimethamine resistance: malaria morbidity and molecular drug resistance profiles in South Sudan.

ABSTRACT:

Background

Seasonal malaria chemoprevention (SMC) using sulfadoxine-pyrimethamine plus amodiaquine (SP-AQ), is a community-based malaria preventive strategy commonly used in the Sahel region of sub-Saharan Africa. However, to date it has not been implemented in East Africa due to high SP resistance levels. This paper is a report on the implementation of SMC outside of the Sahel in an environment with a high level of presumed SP-resistance: five cycles of SMC using SPAQ were administered to children 3-59 months during a period of high malaria transmission (July-December 2019) in 21 villages in South Sudan.

Methods

A population-based SMC coverage survey was combined with a longitudinal time series analysis of health facility and community health data measured after each SMC cy

SUBMITTER: Molina-de la Fuente I 

PROVIDER: S-EPMC10637007 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature