Prediction of breast cancer risk for sisters of women attending screening.

ABSTRACT:

Background

Risk assessment is important for breast cancer prevention and early detection. We aimed to examine whether common risk factors, mammographic features, and breast cancer risk prediction scores of a woman were associated with breast cancer risk for her sisters.

Methods

We included 53 051 women from the Karolinska Mammography Project for Risk Prediction of Breast Cancer (KARMA) study. Established risk factors were derived using self-reported questionnaires, mammograms, and single nucleotide polymorphism genotyping. Using the Swedish Multi-Generation Register, we identified 32 198 sisters of the KARMA women (including 5352 KARMA participants and 26 846 nonparticipants). Cox models were used to estimate the hazard ratios of breast cancer for both women and their sister

SUBMITTER: Mao X 

PROVIDER: S-EPMC10637039 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature