Suitability of respiratory endoscopy for sampling malignant thoracic tumors for comprehensive genomic profiling.

ABSTRACT: Comprehensive genomic profiling (CGP) is implemented to detect actionable gene aberrations and design matched therapies. Although malignant thoracic tumors are commonly detected through respiratory endoscopy, it is questionable whether the small specimens obtained thereof are sufficient for CGP. Therefore, this study aimed to investigate the suitability of respiratory endoscopy for sampling primary and metastatic thoracic tumors for CGP. Patients whose specimens were collected through respiratory endoscopy and assessed by pathologists to determine their suitability for CGP at our institution between June 2019 and May 2022 were reviewed retrospectively. The suitability of each procedure as a sampling technique for CGP and, in the cases actually analyzed, the distribution of the detected gen

SUBMITTER: Fujimoto K 

PROVIDER: S-EPMC10637053 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature