Increased mitochondria are responsible for the acquisition of gemcitabine resistance in pancreatic cancer cell lines.

ABSTRACT: Pancreatic ductal adenocarcinoma has a particularly poor prognosis as it is often detected at an advanced stage and acquires resistance to chemotherapy early during its course. Stress adaptations by mitochondria, such as metabolic plasticity and regulation of apoptosis, promote cancer cell survival; however, the relationship between mitochondrial dynamics and chemoresistance in pancreatic ductal adenocarcinoma remains unclear. We here established human pancreatic cancer cell lines resistant to gemcitabine from MIA PaCa-2 and Panc1 cells. We compared the cells before and after the acquisition of gemcitabine resistance to investigate the mitochondrial dynamics and protein expression that contribute to this resistance. The mitochondrial number increased in gemcitabine-resistant cells after re

SUBMITTER: Masuo H 

PROVIDER: S-EPMC10637055 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature