Distinct functions between ferrous and ferric iron in lung cancer cell growth.

ABSTRACT: Accumulating evidence suggests an association between iron metabolism and lung cancer progression. In biological systems, iron is present in either reduced (Fe²⁺ ; ferrous) or oxidized (Fe³⁺ ; ferric) states. However, ferrous and ferric iron exhibit distinct chemical and biological properties, the role of ferrous and ferric iron in lung cancer cell growth has not been clearly distinguished. In this study, we manipulated the balance between cellular ferrous and ferric iron status by inducing gene mutations involving the FBXL5-IRP2 axis, a ubiquitin-dependent regulatory system for cellular iron homeostasis, and determined its effects on lung cancer cell growth. FBXL5 depletion (ferrous iron accumulation) was found to suppress lung cancer cell growth, whereas IRP2 deplet

SUBMITTER: Hinokuma H 

PROVIDER: S-EPMC10637068 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature