Optical coherence tomography versus other biomarkers: Associations with physical and cognitive disability in multiple sclerosis.

ABSTRACT:

Background

Optical coherence tomography (OCT) is a biomarker of neuroaxonal loss in multiple sclerosis (MS).

Objective

The objective was to assess the relative role of OCT, next to magnetic resonance imaging (MRI) and serum markers of disability in MS.

Methods

A total of 100 patients and 52 controls underwent OCT to determine peripapillary retinal nerve fiber layer (pRNFL) and ganglion cell-inner plexiform layers (GCIPL). Serum neurofilament light chain (sNfL), total lesion volume (TLV), and brain parenchymal fraction (BPF) were also assessed. The associations of OCT with disability were examined in linear regression models with correction for age, vision, and education.

Results

In patients, pRNFL was associated with the Symbol Digit Modalities Test (SDMT; p

SUBMITTER: Cerda-Fuertes N 

PROVIDER: S-EPMC10637109 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature