Toward a more precise prognostic stratification in acute decompensation of cirrhosis: The Padua model 2.0.

ABSTRACT:

Background

The clinical course of acutely decompensated cirrhosis (AD) is heterogeneous. Presepsin (PSP) is a plasmatic biomarker that reflects Toll-like receptor activity and systemic inflammation. We conducted a prospective study to: (1) measure PSP in AD and (2) assess whether PSP in AD can predict the development of acute-on-chronic liver failure (ACLF).

Methods

Patients with AD were prospectively recruited at admission and underwent determination of PSP. In study part 1, we compared PSP in AD versus controls (stable decompensated and compensated cirrhosis). In study part 2, we prospectively followed patients with AD for 1 year and evaluated predictors of ACLF.

Results

One hundred and seventy three patients with AD were included (median MELD: 18; CLIF-C AD score:

SUBMITTER: Zanetto A 

PROVIDER: S-EPMC10637119 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature