Correlations between comorbidities in trials and the community: An individual-level participant data meta-analysis.

ABSTRACT:

Background

People with comorbidities are under-represented in randomised controlled trials, and it is unknown whether patterns of comorbidity are similar in trials and the community.

Methods

Individual-level participant data were obtained for 83 clinical trials (54,688 participants) for 16 index conditions from two trial repositories: Yale University Open Data Access (YODA) and the Centre for Global Clinical Research Data (Vivli). Community data (860,177 individuals) were extracted from the Secure Anonymised Information Linkage (SAIL) databank for the same index conditions. Comorbidities were defined using concomitant medications. For each index condition, we estimated correlations between comorbidities separately in trials and community data. For the six commonest comorbidi

SUBMITTER: Crowther J 

PROVIDER: S-EPMC10637135 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature