Imaging Histology Correlations of Intraretinal Fluid in Neovascular Age-Related Macular Degeneration.

ABSTRACT:

Purpose

Fluid presence and dynamism is central to the diagnosis and management of neovascular age-related macular degeneration. On optical coherence tomography (OCT), some hyporeflective spaces arise through vascular permeability (exudation) and others arise through degeneration (transudation). Herein we determined whether the histological appearance of fluid manifested this heterogeneity.

Methods

Two eyes of a White woman in her 90s with anti-vascular endothelial growth factor treated bilateral type 3 neovascularization secondary to age-related macular degeneration were osmicated, prepared for submicrometer epoxy resin sections, and correlated to eye-tracked spectral domain OCT. Examples of intraretinal tissue fluid were sought among similarly prepared donor eyes with fibro

SUBMITTER: Berlin A 

PROVIDER: S-EPMC10637202 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature