Transcriptional and bioinformatic analysis of GABA_A receptors expressed in oligodendrocyte progenitor cells from the human brain.

ABSTRACT:

Introduction

Oligodendrocyte progenitor cells (OPCs) are vital for neuronal myelination and remyelination in the central nervous system. While the molecular mechanisms involved in OPCs' differentiation and maturation are not completely understood, GABA is known to positively influence these processes through the activation of GABA_A receptors (GABA_ARs). The molecular identity of GABA_ARs expressed in human OPCs remains unknown, which restricts their specific pharmacological modulation to directly assess their role in oligodendrocytes' maturation and remyelination.

Methods

In this study, we conducted a transcriptomic analysis to investigate the molecular stoichiometry of GABA_ARs in OPCs from the human brain. Using eight available tran

SUBMITTER: Gutierrez BA 

PROVIDER: S-EPMC10637375 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature