Causality between urate levels with sarcopenia-related traits: a bi-directional Mendelian randomization study.

ABSTRACT:

Background

Observational studies have suggested associations between serum urate levels and sarcopenia, but the causality underlying this correlation remains uncertain. The principal objective of this study is to investigate a causal relationship of serum urate levels with sarcopenia-related traits (hand grip strength, lean mass, walking pace) using bidirectional two-sample Mendelian randomization (MR) approach. The utilization of MR methodology serves to minimize bias caused by reverse causality and confounding factors from observational studies.

Methods

The summary statistics of serum urate levels were derived from a cohort consisting of 288,659 individuals participating in CKDGen study. The parameters of right-hand grip strength (N=461,089), left-hand grip strength (N=461

SUBMITTER: Lin Y 

PROVIDER: S-EPMC10637380 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature