Altered brain functional networks in schizophrenia with persistent negative symptoms: an activation likelihood estimation meta-analysis.

ABSTRACT:

Objective

To investigate brain structural and functional characteristics of three brain functional networks including default mode network (DMN), central executive network (CEN), and salience network (SN) in persistent negative symptoms (PNS) patients.

Methods

We performed an activation likelihood estimation (ALE) meta-analysis of functional connectivity (FC) studies and voxel-based morphometry (VBM) studies to detect specific structural and functional alterations of brain networks between PNS patients and healthy controls.

Results

Seventeen VBM studies and twenty FC studies were included. In the DMN, PNS patients showed decreased gray matter in the bilateral medial frontal gyrus and left anterior cingulate gyrus and a significant reduction of FC in the right precuneu

SUBMITTER: Zhu T 

PROVIDER: S-EPMC10637389 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature