Minocycline in depression not responding to first-line therapy: A systematic review and meta-analysis.

ABSTRACT:

Background

Major depressive disorder is often resistant to first-line treatment, with around 30% failing to respond to traditional therapy. Treatment-resistant depression results in prolonged hospitalization and healthcare costs. Anti-inflammatory drugs have shown promising results in depression not responding to initial therapy. Minocycline has anti-inflammatory properties and crosses the blood-brain barrier. It has demonstrated varied results in several randomized controlled trials (RCTs).

Methods

We assessed the efficacy of minocycline compared to placebo in depression not responding to one first-line antidepressant via a systematic review and meta-analysis. We performed a comprehensive literature search across PubMed, Cochrane, and Scopus for RCTs. We visualized the resu

SUBMITTER: Shamim MA 

PROVIDER: S-EPMC10637431 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature