Review of molecular biological research on the treatment of membranous nephropathy with Tripterygium glycosides based on TCM theory.

ABSTRACT: To explore the mechanism of Tripterygium wilfordii polyglycoside (TWP) in the treatment of membranous nephropathy (MN) by network pharmacology. TCMSP and DrugBank databases were used to screen the main targets of the main active components of Tripterygium glycosides, and OMIM and Gene Cards databases were used to search the gene targets of MN. UniProt database was used to normalize all the targets to get the intersection targets of TGs and MNs. Synergistic genes were uploaded to the STRING platform to construct a protein-protein interaction network and screen related core targets. Gene Ontology and Kyoto Genome Encyclopedia analyses of core targets were performed using the DAVID database. AutoDockTools software was used to verify the molecular docking between the active components of TGs a

SUBMITTER: Xu P 

PROVIDER: S-EPMC10637535 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature