Biological and clinical significance of the glypican-3 gene in human lung adenocarcinoma: An in silico analysis.

ABSTRACT: Glypican-3 (GPC3), a membrane-bound heparan sulfate proteoglycan, has long been found to be dysregulated in human lung adenocarcinomas (LUADs). Nevertheless, the function, mutational profile, epigenetic regulation, co-expression profile, and clinicopathological significance of the GPC3 gene in LUAD progression are not well understood. In this study, we analyzed cancer microarray datasets from publicly available databases using bioinformatics tools to elucidate the above parameters. We observed significant downregulation of GPC3 in LUAD tissues compared to their normal counterparts, and this downregulation was associated with shorter overall survival (OS) and relapse-free survival (RFS). Nevertheless, no significant differences in the methylation pattern of GPC3 were observed between LUAD a

SUBMITTER: Imon RR 

PROVIDER: S-EPMC10637541 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature