Deep phenotyping of the lipidomic response in COVID-19 and non-COVID-19 sepsis.

ABSTRACT:

Background

Lipids may influence cellular penetrance by viral pathogens and the immune response that they evoke. We deeply phenotyped the lipidomic response to SARs-CoV-2 and compared that with infection with other pathogens in patients admitted with acute respiratory distress syndrome to an intensive care unit (ICU).

Methods

Mass spectrometry was used to characterise lipids and relate them to proteins, peripheral cell immunotypes and disease severity.

Results

Circulating phospholipases (sPLA2, cPLA2 (PLA2G4A) and PLA2G2D) were elevated on admission in all ICU groups. Cyclooxygenase, lipoxygenase and epoxygenase products of arachidonic acid (AA) were elevated in all ICU groups compared with controls. sPLA2 predicted severity in COVID-19 and correlated with TxA2, LTE4 a

SUBMITTER: Meng H 

PROVIDER: S-EPMC10637636 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature