Maternal varicella antibodies in children aged less than one year: Assessment of antibody decay.

ABSTRACT:

Objectives

To investigate maternal antibody levels to varicella in infants <12 months of age in Ontario, Canada.

Study design

In this study, we included specimens from infants <12 months of age, born at ≥37 weeks gestational age, who had sera collected at The Hospital for Sick Children (Toronto, Canada) between 2014-2016. We tested sera using a glycoprotein-based enzyme-linked immunosorbent assay (gpELISA). We measured varicella susceptibility (antibody concentration <150mIU/mL) and mean varicella antibody concentration, and assessed the probability of susceptibility and concentration between one and 11 months of age using multivariable logistic regression and Poisson regression.

Results

We found that 32% of 196 included specimens represented infants susceptible to va

SUBMITTER: Bolotin S 

PROVIDER: S-EPMC10637651 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature