A novel f-divergence based generative adversarial imputation method for scRNA-seq data analysis.

ABSTRACT: Comprehensive analysis of single-cell RNA sequencing (scRNA-seq) data can enhance our understanding of cellular diversity and aid in the development of personalized therapies for individuals. The abundance of missing values, known as dropouts, makes the analysis of scRNA-seq data a challenging task. Most traditional methods made assumptions about specific distributions for missing values, which limit their capability to capture the intricacy of high-dimensional scRNA-seq data. Moreover, the imputation performance of traditional methods decreases with higher missing rates. We propose a novel f-divergence based generative adversarial imputation method, called sc-fGAIN, for the scRNA-seq data imputation. Our studies identify four f-divergence functions, namely cross-entropy, Kullback-Leibler

SUBMITTER: Si T 

PROVIDER: S-EPMC10637660 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature