Transcriptional control of motor pool formation and motor circuit connectivity by the LIM-HD protein Isl2.

ABSTRACT: The fidelity of motor control requires the precise positional arrangement of motor pools and the establishment of synaptic connections between them. During neural development in the spinal cord, motor nerves project to specific target muscles and receive proprioceptive input from these muscles via the sensorimotor circuit. LIM-homeodomain transcription factors are known to play a crucial role in successively restricting specific motor neuronal fates. However, their exact contribution to limb-based motor pools and locomotor circuits has not been fully understood. To address this, we conducted an investigation into the role of Isl2, a LIM-homeodomain transcription factor, in motor pool organization. We found that deletion of Isl2 led to the dispersion of motor pools, primarily affecti

SUBMITTER: Lee Y 

PROVIDER: S-EPMC10637776 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature