Case Series: "Silent" Spinal Epidural Metastases in Metastatic Castrate-Resistant Prostate Cancer.

ABSTRACT:

Introduction

Spinal epidural metastases (SEM) are an uncommon phenomenon and traditionally occur as a preterminal event in heavily pre-treated patients. The introduction of novel anti-androgen therapies, such as enzalutamide and abiraterone acetate, has greatly improved the survival of patients with metastatic prostate cancer but may be changing the pattern of disease.

Case presentation

Four patients diagnosed with metastatic castrate-resistant prostate cancer (CRPC) were commenced on enzalutamide prior to chemotherapy. Baseline scans in all patients demonstrated extensive bony disease and lymph node involvement. All patients experienced a moderate initial PSA response to treatment (median PSA at baseline 53.5 ng/mL to median nadir 24.5 ng/mL). In all four cases, clinical pr

SUBMITTER: Sabanathan D 

PROVIDER: S-EPMC10637777 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature