STK4 is a prognostic biomarker correlated with immune infiltrates in clear cell renal cell carcinoma.

ABSTRACT:

Background

Mammalian STE20-like kinase 1 (MST1/STK4/KRS2) is a highly conserved serine/threonine kinase and a central member of the Hippo signaling pathway. STK4 has been reported to play important roles in various tumors, but a systematic and comprehensive study of its function in clear cell renal cell carcinoma (ccRCC) has not been conducted.

Methods

In this study, we used immunohistochemistry (IHC), western blot (WB), quantitative real-time PCR (qPCR) experiments, and bioinformatics analysis to comprehensively analyze the expression, prognostic value, and immune infiltration of STK4 in ccRCC.

Results

Analysis of the TCGA database showed that the expression level of the STK4 gene in ccRCC patients depended on tumor stage, grade, and distant lymphatic metastasis. Thi

SUBMITTER: Bai ZY 

PROVIDER: S-EPMC10637789 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature