Exosome and lipid metabolism-related genes in pancreatic adenocarcinoma: a prognosis analysis.

ABSTRACT:

Objective

The purpose of the study was to investigate the role of exosome and lipid metabolism-related genes (EALMRGs) mRNA levels in the diagnosis and prognosis of Pancreatic Adenocarcinoma (PAAD).

Methods

The mRNA expression pattern of PAAD and pan-cancers with prognostic data were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database. EALMRGs were acquired from GeneCards and MSigDB database after merging and deduplication. Prognostic EALMRGs were screened through univariate COX regression analysis, and a prognostic model was constructed based on these genes by least absolute shrinkage and selection operator (LASSO) regression. The prognostic value of EALMRGs was then validated in pan-cancer data. The time characteristics ROC curve analysi

SUBMITTER: Wu J 

PROVIDER: S-EPMC10637811 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature