The <i>Saccharomyces cerevisiae</i> acetyltransferase Gcn5 exerts antagonistic pleiotropic effects on chronological ageing.

ABSTRACT: Compared to replicative lifespan, epigenetic regulation of chronological lifespan (CLS) is less well understood in yeast. Here, by screening all the viable mutants of histone acetyltransferase (HAT) and histone deacetylase (HDAC), we demonstrate that Gcn5, functioning in the HAT module of the SAGA/SLIK complex, exhibits an epistatic relationship with the HDAC Hda1 to control the expression of starvation-induced stress response and respiratory cell growth. Surprisingly, the gcn5Δ mutants lose their colony-forming potential early in the stationary phase but display a longer maximum CLS than their WT counterparts, suggesting the contradictory roles of Gcn5 in lifespan regulation. Integrative analyses of the transcriptome, metabolome and ChIP assays reveal that Gcn5 is necessary for the

SUBMITTER: Li K 

PROVIDER: S-EPMC10637828 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature