Open MoA: revealing the mechanism of action (MoA) based on network topology and hierarchy.

ABSTRACT:

Motivation

Many approaches in systems biology have been applied in drug repositioning due to the increased availability of the omics data and computational biology tools. Using a multi-omics integrated network, which contains information of various biological interactions, could offer a more comprehensive inspective and interpretation for the drug mechanism of action (MoA).

Results

We developed a computational pipeline for dissecting the hidden MoAs of drugs (Open MoA). Our pipeline computes confidence scores to edges that represent connections between genes/proteins in the integrated network. The interactions showing the highest confidence score could indicate potential drug targets and infer the underlying molecular MoAs. Open MoA was also validated by testing some well-es

SUBMITTER: Liao X 

PROVIDER: S-EPMC10637856 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature