Nanotechnologies meeting natural sources: Engineered lipoproteins for precise brain disease theranostics.

ABSTRACT: Biological nanotechnologies have provided considerable opportunities in the management of malignancies with delicate design and negligible toxicity, from preventive and diagnostic to therapeutic fields. Lipoproteins, because of their inherent blood-brain barrier permeability and lesion-homing capability, have been identified as promising strategies for high-performance theranostics of brain diseases. However, the application of natural lipoproteins remains limited owing to insufficient accumulation and complex purification processes, which can be critical for individual therapeutics and clinical translation. To address these issues, lipoprotein-inspired nano drug-delivery systems (nano-DDSs), which have been learned from nature, have been fabricated to achieve synergistic drug delivery inv

SUBMITTER: Wang R 

PROVIDER: S-EPMC10637878 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature