Bacopa monnieri: A promising herbal approach for neurodegenerative disease treatment supported by in silico and in vitro research.

ABSTRACT: Neurodegenerative disorders, caused by progressive neuron loss, are a global health issue. Among the various factors implicated in their pathogenesis, dysregulation of acetylcholinesterase activity has been recognized as a key contributor. Acetylcholinesterase breaks down the neurotransmitter acetylcholine, important for neural transmission. Evaluating phyto-compounds from Bacopa monnieri Linn. through in vitro and in silico analysis may expand their role as alternative therapeutic agents by modulating the function of acetylcholinesterase and complementing existing treatments. To accomplish this objective, chemical structures of phyto-compounds were retrieved from PubChem database and subjected to in silico and in vitro approaches. Virtual screening was p

SUBMITTER: Shoukat S 

PROVIDER: S-EPMC10637926 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature