Targeting cuproptosis by zinc pyrithione in triple-negative breast cancer.
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ABSTRACT:
SUBMITTER: Yang X
PROVIDER: S-EPMC10637938 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Publications
Targeting cuproptosis by zinc pyrithione in triple-negative breast cancer.
Yang Xu X Deng Li L Diao Xianhong X Yang Siyuan S Zou Li L Yang Qin Q Li Jian J Nie Jianyun J Zhao Lina L Jiao Baowei B
iScience 20231016 11
Triple-negative breast cancer (TNBC) poses a considerable challenge due to its aggressive nature. Notably, metal ion-induced cell death, such as ferroptosis, has garnered significant attention and demonstrated potential implications for cancer. Recently, cuproptosis, a potent cell death pathway reliant on copper, has been identified. However, whether cuproptosis can be targeted for cancer treatment remains uncertain. Here, we screened the US Food and Drug Administration (FDA)-approved drug libra ...[more]
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