C-kit^pos cells in the human left atrial appendage.

ABSTRACT:

Background

Subpopulations of myocardial c-kit^pos cells have the ability to stimulate regeneration in ischemic heart disease by paracrine effects. The left atrial appendage (LAA), which is easy accessible during cardiac surgery, may represent a perfect source for c-kit^pos cell extraction for autologous cell therapies in the living human. So far, frequency and distribution of c-kit^pos cells in LAA are unknown.

Methods

LAAs of patients who underwent cardiac surgery due to coronary artery disease (coronary artery bypass graft, CABG), valvular heart disease or both and of two body donors were examined. Tissue was fixed in 4 % paraformaldehyde, embedded in paraffin, dissected in consecutive sections and stained for c-kit^pos cells. In par

SUBMITTER: Schwarzkopf L 

PROVIDER: S-EPMC10637945 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature