The relationship between alcohol- and sleep-related traits: Results from polygenic risk score and Mendelian randomization analyses.

ABSTRACT:

Study objectives

We investigated whether genetic risk for insomnia and sleep duration abnormalities are associated with AUD and alcohol consumption. We also evaluated the causal relationships between sleep- and alcohol-related traits.

Methods

Individual-level phenotype and genotype data from the Million Veteran Program were used. Polygenic risk scores (PRS) were computed using summary statistics from two recent discovery GWAS of insomnia (N= 453,379 European-ancestry (EA) individuals) and sleep duration (N= 446,118 EAs) and tested for association with lifetime AUD diagnosis (N= 34,658 EA cases) and past-year Alcohol Use Disorders Identification Test-Consumption scale scores (AUDIT-C, N= 200,680 EAs). Bi-directional two-sample Mendelian Randomization (MR) analyses assessed ca

SUBMITTER: Chakravorty S 

PROVIDER: S-EPMC10638060 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature