Genetic predictors of neurocognitive outcomes in survivors of pediatric brain tumors.

ABSTRACT:

Background

Neurocognitive deficits are common in pediatric brain tumor survivors. The use of single nucleotide polymorphism (SNP) analysis in DNA repair genes may identify children treated with radiation therapy for brain tumors at increased risk for treatment toxicity and adverse neurocognitive outcomes.

Materials

The Human 660W-Quad v1.0 DNA BeadChip analysis (Illumina) was used to evaluate 1048 SNPs from 59 DNA repair genes in 46 subjects. IQ testing was measured by the Wechsler Intelligence Scale for Children. Linear regression was used to identify the 10 SNPs with the strongest association with IQ scores while adjusting for radiation type.

Results

The low vs high IQ patient cohorts were well matched for time from first treatment to most recent IQ, first treatment

SUBMITTER: Grob ST 

PROVIDER: S-EPMC10638163 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature