An update on the use of image-derived input functions for human PET studies: new hopes or old illusions?

ABSTRACT:

Background

The need for arterial blood data in quantitative PET research limits the wider usability of this imaging method in clinical research settings. Image-derived input function (IDIF) approaches have been proposed as a cost-effective and non-invasive alternative to gold-standard arterial sampling. However, this approach comes with its own limitations-partial volume effects and radiometabolite correction among the most important-and varying rates of success, and the use of IDIF for brain PET has been particularly troublesome.

Main body

This paper summarizes the limitations of IDIF methods for quantitative PET imaging and discusses some of the advances that may make IDIF extraction more reliable. The introduction of automated pipelines (both commercial and open-source) f

SUBMITTER: Volpi T 

PROVIDER: S-EPMC10638226 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature