A quantitative evaluation method utilizing the homology concept to assess the state of chromatin within the nucleus of lung cancer.

ABSTRACT: Homology is a mathematical tool to quantify "the contact degree", which can be expressed in terms of Betti numbers. The Betti numbers used in this study consisted of two numbers, b0 (a zero-dimensional Betti number) and b1 (a one-dimensional Betti number). We developed a chromatin homology profile (CHP) method to quantify the chromatin contact degree based on this mathematical tool. Using the CHP method we analyzed the number of holes (surrounded areas = b1 value) formed by the chromatin contact and calculated the maximum value of b1 (b1MAX), the value of b1 exceeding 5 for the first time or Homology Value (HV), and the chromatin density (b1MAX/ns²). We attempted to detect differences in chromatin patterns and differentiate histological types of lung cancer from respiratory cyto

SUBMITTER: Yokoyama Y 

PROVIDER: S-EPMC10638289 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature