Histology-informed multiscale modeling of human brain white matter.

ABSTRACT: In this study, we propose a novel micromechanical model for the brain white matter, which is described as a heterogeneous material with a complex network of axon fibers embedded in a soft ground matrix. We developed this model in the framework of RVE-based multiscale theories in combination with the finite element method and the embedded element technique for embedding the fibers. Microstructural features such as axon diameter, orientation and tortuosity are incorporated into the model through distributions derived from histological data. The constitutive law of both the fibers and the matrix is described by isotropic one-term Ogden functions. The hyperelastic response of the tissue is derived by homogenizing the microscopic stress fields with multiscale boundary conditions to ensure kinem

SUBMITTER: Saeidi S 

PROVIDER: S-EPMC10638412 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature