Microstimulation of human somatosensory cortex evokes task-dependent, spatially patterned responses in motor cortex.

ABSTRACT: The primary motor (M1) and somatosensory (S1) cortices play critical roles in motor control but the signaling between these structures is poorly understood. To fill this gap, we recorded - in three participants in an ongoing human clinical trial (NCT01894802) for people with paralyzed hands - the responses evoked in the hand and arm representations of M1 during intracortical microstimulation (ICMS) in the hand representation of S1. We found that ICMS of S1 activated some M1 neurons at short, fixed latencies consistent with monosynaptic activation. Additionally, most of the ICMS-evoked responses in M1 were more variable in time, suggesting indirect effects of stimulation. The spatial pattern of M1 activation varied systematically: S1 electrodes that elicited percepts in a finger preferentia

SUBMITTER: Shelchkova ND 

PROVIDER: S-EPMC10638421 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature