Treating the Side Effects of Exogenous Glucocorticoids; Can We Separate the Good From the Bad?

ABSTRACT: It is estimated that 2% to 3% of the population are currently prescribed systemic or topical glucocorticoid treatment. The potent anti-inflammatory action of glucocorticoids to deliver therapeutic benefit is not in doubt. However, the side effects associated with their use, including central weight gain, hypertension, insulin resistance, type 2 diabetes (T2D), and osteoporosis, often collectively termed iatrogenic Cushing's syndrome, are associated with a significant health and economic burden. The precise cellular mechanisms underpinning the differential action of glucocorticoids to drive the desirable and undesirable effects are still not completely understood. Faced with the unmet clinical need to limit glucocorticoid-induced adverse effects alongside ensuring the preservation of anti-i

SUBMITTER: Pofi R 

PROVIDER: S-EPMC10638606 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature