Role of PPAR-related genes in chronic heart failure: evidence from large populations.

ABSTRACT:

Background

The role of PPAR signaling and its associated genes in the pathogenesis and progression of chronic heart failure (CHF) remains elusive.

Methods

We accessed the gene expression profile and relevant baseline information of CHF samples from the Gene Expression Omnibus (GEO) database, specifically from the GSE57338 project.

Results

From GSE57338 project, we derived the expression value of 126 PPAR-related genes. A protein-protein interaction network was then established to illustrate potential protein interactions. ClueGO analysis results revealed that these genes predominantly participate in functions such as export across plasma membrane, regulation of lipid metabolic process, fatty acid metabolism, circulatory system vascular processes, alcohol metabolism, t

SUBMITTER: Ke ZP 

PROVIDER: S-EPMC10638691 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature