Subjective cognitive complaints and blood biomarkers of neurodegenerative diseases: a longitudinal cohort study.

ABSTRACT:

Background

Subjective cognitive complaints (SCC) have been mostly studied in the context of Alzheimer's disease in memory clinic settings. The potential of combining SCC with genetic information and blood biomarkers of neurodegenerative diseases for risk assessment of dementia and depression in the absence of dementia among community-dwelling older adults has so far not been explored.

Methods

Data were based on a population-based cohort of 6357 participants with a 17-year follow-up (ESTHER study) and a clinic-based cohort of 422 patients. Participants of both cohorts were grouped according to the diagnosis of dementia (yes/no) and the diagnosis of depression in the absence of dementia (yes/no). Participants without dementia included both cognitively unimpaired participants a

SUBMITTER: Perna L 

PROVIDER: S-EPMC10638700 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature