Role of environmental specificity in CASP results.

ABSTRACT:

Background

Recently, significant progress has been made in the field of protein structure prediction by the application of artificial intelligence techniques, as shown by the results of the CASP13 and CASP14 (Critical Assessment of Structure Prediction) competition. However, the question of the mechanism behind the protein folding process itself remains unanswered. Correctly predicting the structure also does not solve the problem of, for example, amyloid proteins, where a polypeptide chain with an unaltered sequence adopts a different 3D structure.

Results

This work was an attempt at explaining the structural variation by considering the contribution of the environment to protein structuring. The application of the fuzzy oil drop (FOD) model to assess the validity of the se

SUBMITTER: Roterman I 

PROVIDER: S-EPMC10638730 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature