Anti-diarrheal drug loperamide induces dysbiosis in zebrafish microbiota via bacterial inhibition.

ABSTRACT:

Background

Perturbations of animal-associated microbiomes from chemical stress can affect host physiology and health. While dysbiosis induced by antibiotic treatments and disease is well known, chemical, nonantibiotic drugs have recently been shown to induce changes in microbiome composition, warranting further exploration. Loperamide is an opioid-receptor agonist widely prescribed for treating acute diarrhea in humans. Loperamide is also used as a tool to study the impact of bowel dysfunction in animal models by inducing constipation, but its effect on host-associated microbiota is poorly characterized.

Results

We used conventional and gnotobiotic larval zebrafish models to show that in addition to host-specific effects, loperamide also has anti-bacterial activities that di

SUBMITTER: Stevick RJ 

PROVIDER: S-EPMC10638762 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature