DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study.

ABSTRACT:

Background

Puberty is a highly heritable and variable trait, with environmental factors having a role in its eventual timing and development. Early and late pubertal onset are both associated with various diseases developing later in life, and epigenetic characterisation of pubertal timing and development could lead to important insights. Blood DNA methylation, reacting to both genotype and environment, has been associated with puberty; however, such studies are relatively scarce. We investigated peripheral blood DNA methylation profiles (using Illumina 450 K and EPIC platforms) of 1539 young adult Finnish twins associated with pubertal development scale (PDS) at ages 12 and 14 as well as pubertal age (PA).

Results

Fixed effect meta-analysis of the two platforms on 347,521 C

SUBMITTER: Sehovic E 

PROVIDER: S-EPMC10638786 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature