CD4⁺CCR8⁺ Tregs in ovarian cancer: a potential effector Tregs for immune regulation.

ABSTRACT:

Background

Tregs are key drivers of immunosuppression in solid tumors. As an important chemokine receptor on Tregs, the regulatory effect of CCR8 on tumor immunity has received more and more attention. However, the current research on CCR8 in the immune microenvironment of ovarian cancer has not been clear.

Methods

Bioinformatics analysis was used to compare the transcriptome differences between CD4⁺ T cells in the peripheral circulation and infiltrated in ovarian tumor tissues. RT-PCR was used to detect the expression levels of chemokine receptor-related differential genes on CD4⁺ T cells in peripheral blood and ovarian tumor tissues. Multiparameter flow cytometry was used to detect the proportion and phenotypic characteristics of CD4⁺CCR8

SUBMITTER: Liu S 

PROVIDER: S-EPMC10638792 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature