Estimating and visualising the trade-off between benefits and harms on multiple clinical outcomes in network meta-analysis.

ABSTRACT:

Background

The relative treatment effects estimated from network meta-analysis can be employed to rank treatments from the most preferable to the least preferable option. These treatment hierarchies are typically based on ranking metrics calculated from a single outcome. Some approaches have been proposed in the literature to account for multiple outcomes and individual preferences, such as the coverage area inside a spie chart, that, however, does not account for a trade-off between efficacy and safety outcomes. We present the net-benefit standardised area within a spie chart, [Formula: see text] to explore the changes in treatment performance with different trade-offs between benefits and harms, according to a particular set of preferences.

Methods

We combine the standardi

SUBMITTER: Chiocchia V 

PROVIDER: S-EPMC10638812 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature