Prediction factors and clinical significance of different types of hemorrhagic transformation after intravenous thrombolysis.

ABSTRACT:

Background and purpose

Hemorrhagic transformation (HT) after intravenous thrombolysis (IVT) in acute ischemic stroke seriously affects the prognosis of patients. This study aimed to investigate the risk factors of different types of HT and their correlation with prognosis after IVT.

Methods

Based on the CASE II registry, we included patients with acute ischemic stroke who received IVT within 4.5 h of onset. HT was further divided into hemorrhagic infarction (HI) and parenchymal hemorrhage (PH). Poor outcome was defined as a modified Rankin Scale (mRS) score of 3-6 at 3 months. Multivariate logistic regression analysis was used to determine the independent influencing factors of HT subtypes and clinical outcome.

Results

Among 13108 included patients, 541 (4.1%) develop

SUBMITTER: Hao Y 

PROVIDER: S-EPMC10638828 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature