The effects of acute Methylene Blue administration on cerebral blood flow and metabolism in humans and rats.

ABSTRACT: Methylene Blue (MB) is a brain-penetrating drug with putative neuroprotective, antioxidant and metabolic enhancing effects. In vitro studies suggest that MB enhances mitochondrial complexes activity. However, no study has directly assessed the metabolic effects of MB in the human brain. We used in vivo neuroimaging to measure the effect of MB on cerebral blood flow (CBF) and brain metabolism in humans and in rats. Two doses of MB (0.5 and 1 mg/kg in humans; 2 and 4 mg/kg in rats; iv) induced reductions in global cerebral blood flow (CBF) in humans (F_{(1.74, 12.17)}5.82, p = 0.02) and rats (F_(1,5)26.04, p = 0.0038). Human cerebral metabolic rate of oxygen (CMRO₂) was also significantly reduced (F_{(1.26, 8.84)}8.01, p = 0.016), as was the

SUBMITTER: Singh N 

PROVIDER: S-EPMC10638993 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature