NAD⁺ precursor nutritional supplements sensitize the brain to future ischemic events.

ABSTRACT: Nicotinamide adenine dinucleotide (NAD⁺) is a redox cofactor critical for oxidative phosphorylation. Nicotinamide (NAM) and nicotinamide riboside (NR) are NAD⁺ precursors widely used as nutritional supplements to augment oxidative phosphorylation. Indeed, NAD⁺ precursors have been reported to improve outcomes in ischemic stroke when administered as a rescue therapy after stroke onset. However, we have also reported that enhanced reliance on oxidative phosphorylation before ischemia onset might worsen outcomes. To address the paradox, we examined how NAD⁺ precursors modulate the outcome of middle cerebral artery occlusion in mice, when administered either 20 minutes after reperfusion or daily for three days before ischemia onset. A single post-isc

SUBMITTER: Qu W 

PROVIDER: S-EPMC10638999 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature