An mRNA vaccine against rabies provides strong and durable protection in mice.

ABSTRACT:

Introduction

Rabies is a serious public health problem worldwide for which an effective treatment method is lacking but can be prevented by vaccines. Current vaccines are produced in cell or egg cultures, which are both costly and time consuming.

Methods

Here, a non-replicating mRNA vaccine (RV021) encoding the rabies virus glycoprotein was developed in vitro, and its immunogenicity and protective efficacy against live virus was evaluated in mice.

Results

A two-dose vaccination with 1 μg of RV021 at 7-day intervals induced a protective level of neutralizing antibody that was maintained for at least 260 days. RV021 induced a robust cellular immune response that was significantly superior to that of an inactivated vaccine. Two doses of 1 μg RV021 provided full pr

SUBMITTER: Li M 

PROVIDER: S-EPMC10639119 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature