Antigen specific activation of cytotoxic CD8⁺ T cells by Staphylococcus aureus infected dendritic cells.

ABSTRACT: Staphylococcus aureus (S. aureus) is a pathogen associated with a wide variety of diseases, from minor to life-threatening infections. Antibiotic-resistant strains have emerged, leading to increasing concern about the control of S. aureus infections. The development of vaccines may be one way to overcome these resistant strains. However, S. aureus ability to internalize into cells - and thus to form a reservoir escaping humoral immunity - is a challenge for vaccine development. A role of T cells in the elimination of persistent S. aureus has been established in mice but it remains to be established if CD8⁺ T cells could display a cytotoxic activity against S. aureus infected cells. We examined in vitro the ability of CD8⁺

SUBMITTER: Friot A 

PROVIDER: S-EPMC10639145 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature