FooDrugs: a comprehensive food-drug interactions database with text documents and transcriptional data.

ABSTRACT: Food-drug interactions (FDIs) occur when a food item alters the pharmacokinetics or pharmacodynamics of a drug. FDIs can be clinically relevant, as they can hamper or enhance the therapeutic effects of a drug and impact both their efficacy and their safety. However, knowledge of FDIs in clinical practice is limited. This is partially due to the lack of resources focused on FDIs. Here, we describe FooDrugs, a database that centralizes FDI knowledge retrieved from two different approaches: a natural processing language pipeline that extracts potential FDIs from scientific documents and clinical trials and a molecular similarity approach based on the comparison of gene expression alterations caused by foods and drugs. FooDrugs database stores a total of 3 430 062 potential FDIs, with 1 108 42

SUBMITTER: Lacruz-Pleguezuelos B 

PROVIDER: S-EPMC10640380 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature