Mucosal Melanoma: Epidemiology, Clinical Features, and Treatment.

ABSTRACT:

Purpose of review

Summarize the writings published in the last years on the management and novel therapies of mucosal melanoma (MM).

Recent findings

New research has demonstrated a difference between MM and cutaneous melanoma (CM) in their genomic and molecular landscapes, explaining the response's heterogeneity. Immunotherapy and targeted therapy have limited benefit, but novel therapies are rapidly expanding. MM is aggressive cancer occurring in gastrointestinal, respiratory, or urogenital mucosa; whose incidence is greater in the Asian population. The etiology and pathogenesis remain unclear since UV exposure is not a proven risk factor as in cutaneous melanoma. In contrast to CM, lesions on the mucosal surface are less likely to be recognized early; therefore, the diseas

SUBMITTER: Sergi MC 

PROVIDER: S-EPMC10640506 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature