Emergence of task-related spatiotemporal population dynamics in transplanted neurons.

ABSTRACT: Loss of nervous system tissue after severe brain injury is a main determinant of poor functional recovery. Cell transplantation is a promising method to restore lost tissue and function, yet it remains unclear if transplanted neurons can demonstrate the population level dynamics important for movement control. Here we present a comprehensive approach for long-term single neuron monitoring and manipulation of transplanted embryonic cortical neurons after cortical injury in adult male mice performing a prehension task. The observed patterns of population activity in the transplanted network strongly resembled that of healthy networks. Specifically, the task-related spatiotemporal activity patterns of transplanted neurons could be represented by latent factors that evolve within a low dimensi

SUBMITTER: Ghuman H 

PROVIDER: S-EPMC10640594 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature